Production of tetravalent dengue virus envelope protein domain III based antigens in lettuce chloroplasts and immunologic analysis for future oral vaccine development
نویسندگان
چکیده
منابع مشابه
Neutralizing Antibody Response and Efficacy of Novel Recombinant Tetravalent Dengue DNA Vaccine Comprising Envelope Domain III in Mice
Background: Dengue is a global arboviral threat to humans; causing 390 million infections per year. The availability of safe and effective tetravalent dengue vaccine is a global requirement to prevent epidemics, morbidity, and mortality associated with it. Methods: Five experimental groups (6 mice per group) each of 5-week-old BALB/c mice were immunized with vaccine and placebo (empty plasmid) ...
متن کاملDengue virus type-3 envelope protein domain III; expression and immunogenicity
Objective(s): Production of a recombinant and immunogenic antigen using dengue virus type-3 envelope protein is a key point in dengue vaccine development and diagnostic researches. The goals of this study were providing a recombinant protein from dengue virus type-3 envelope protein and evaluation of its immunogenicity in mice. Materials and Methods: Multiple amino acid sequences of different i...
متن کاملneutralizing antibody response and efficacy of novel recombinant tetravalent dengue dna vaccine comprising envelope domain iii in mice
background: dengue is a global arboviral threat to humans; causing 390 million infections per year. the availability of safe and effective tetravalent dengue vaccine is a global requirement to prevent epidemics, morbidity, and mortality associated with it. methods: five experimental groups (6 mice per group) each of 5-week-old balb/c mice were immunized with vaccine and placebo (empty plasmid) ...
متن کاملdengue virus type-3 envelope protein domain iii; expression and immunogenicity
objective(s): production of a recombinant and immunogenic antigen using dengue virus type-3 envelope protein is a key point in dengue vaccine development and diagnostic researches. the goals of this study were providing a recombinant protein from dengue virus type-3 envelope protein and evaluation of its immunogenicity in mice. materials and methods: multiple amino acid sequences of different i...
متن کاملEnvelope-modified tetravalent dengue virus-like particle vaccine: implication for flavivirus vaccine design
16 Dengue viruses (DENV) infect 50-100 million people each year. The spread of DENV17 associated infections is one of the most serious public health problems worldwide, as there is no 18 widely available vaccine or specific therapeutic for DENV infections. To address this, we 19 developed a novel tetravalent dengue vaccine utilizing virus-like particle (VLP) technology. We 20 created recombinan...
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ژورنال
عنوان ژورنال: Plant Biotechnology Journal
سال: 2019
ISSN: 1467-7644,1467-7652
DOI: 10.1111/pbi.13065